Table 1. General characteristics of included studies.
| Study (Country) | Design | Population | Number of included patients | Interventions | Compliance assessment | Study duration (follow-up points) |
|---|---|---|---|---|---|---|
| Grossi et al. 1996 (USA) | RCT | 42 essentially type 2 poorly controlled diabetic with severe periodontitis | Test = 18 | Test = SRP + H20 irrigation + systemic doxycycline 100 mg/day for 2 weeks | Not reported | 12 months (3, 6, and 12 months) |
| Control = 24 | Control = SRP + H20 irrigation + placebo | |||||
| Deo et al. 2010 (India) | RCT | 20 diabetic patients with chronic periodontitis (mean age: 37.1 ± 3.96) | Test = 10 | Test = SRP + doxycycline hyclate 20 mg twice a day for the treatment period of six months | Not reported | 6 months |
| Control = 10 | Control = SRP + placebo capsule b.i.d. for the treatment period of six months | |||||
| Botero et al. 2013 (Colombia) | Double blind RCT | 70 type 1 and type 2 poorly controlled diabetics patients with moderate periodontitis (mean age: test = 55.9±12.6; control = 58.2±11.1) | Test = 33 | Test = SRP + azithromycin 500mg/day for 3 days | Not reported | 9 months (3, 6, and 9 months) |
| Control = 37 | Control = SRP + placebo 500mg/day for 3 days | |||||
| Miranda et al. 2014 (Brazil) | Double blind RCT | 56 type 2 poorly controlled diabetics with generalized chronic periodontitis (mean age: test = 54.0±8.2; control = 53.7±8.0) | Test = 29 | Test = SRP + MTZ (400 mg thrice a day [TID] for 14 days) + AMX (500 mg TID for 14 days) | 3 control subjects and one test subject had 1 or 2 pills left in the bottles on Day 14 | 12 months (3, 6, and 12 months) |
| Control = 27 | Control = SRP + placebo for 14 days | |||||
| Tsalikis et al. 2014 (Greece) | Double blind RCT | 66 type 2 well controlled diabetics with moderate or advanced periodontitis (mean age: test = 62.9±10.0; control = 57.9±8.2) | Test = 31 | Test = SRP + doxycycline (200 mg as loading dose and 100 mg for 20 days) | All patients followed the prescribed regimen | 6 months (3 and 6 months) |
| Control = 35 | Control = SRP + placebo with the same instructions |
RCT = randomized clinical trial. SRP = scaling and root planing. MTZ = metronidazole. AMX = amoxicillin.