Table 2. Quality assessment of included studies evaluating the efficacy of nalmefene in the treatment of adult alcohol dependence (main analysis).

Study	Sequence Generation	Allocation Concealment	Blinding	Incomplete Outcome Data	Selective Outcome Reporting	Other Source of Bias
Gual et al. (12023A)	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Mann et al. (12014A)	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Karhuvaara et al. (CPH-101-801)	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
CPH-101-0701	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
van den Brink et al. (12013A)	Low risk	Low risk	Low risk	High risk	Low risk	Low risk

Each study was assessed for methodological quality using a standardized critical appraisal instrument (the Cochrane Collaboration tool for assessing risk of bias).