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. 2015 Dec 22;12(12):e1001924. doi: 10.1371/journal.pmed.1001924

Table 2. Quality assessment of included studies evaluating the efficacy of nalmefene in the treatment of adult alcohol dependence (main analysis).

Study Sequence Generation Allocation Concealment Blinding Incomplete Outcome Data Selective Outcome Reporting Other Source of Bias
Gual et al. (12023A) Low risk Low risk Low risk High risk Low risk Low risk
Mann et al. (12014A) Low risk Low risk Low risk High risk Low risk Low risk
Karhuvaara et al. (CPH-101-801) Low risk Low risk Low risk High risk Low risk Low risk
CPH-101-0701 Low risk Low risk Low risk High risk Low risk Low risk
van den Brink et al. (12013A) Low risk Low risk Low risk High risk Low risk Low risk

Each study was assessed for methodological quality using a standardized critical appraisal instrument (the Cochrane Collaboration tool for assessing risk of bias).