Table 5.
Production of NO and ROS IPA canonical pathway
| Symbol | GeneID | DFA.OE | DFA.OI | D2a.OE | D2a.OI |
|---|---|---|---|---|---|
| Nfkbia | 25493 | 1.853* | 1.919* | 1.366 | 1.306 |
| Rbp4 | 25703 | 2.96* | 2.555* | 1.275 | 0.436* |
| Ppp2cb | 24673 | 0.682* | 0.598* | 0.779 | 0.916 |
| Map3k12 | 25579 | 0.809 | 0.49* | 0.798 | 0.836 |
| Fos | 314322 | 0.346* | 0.325* | 0.976 | 0.983 |
| Akt1 | 24185 | 0.673* | 0.549* | 0.979 | 1.146 |
| Crebbp | 54244 | 0.927 | 0.662* | 0.964 | 1.049 |
| Rac1 | 363875 | 0.59* | 0.61* | 1.207 | 1.275 |
| Map3k7 | 313121 | 0.762* | 0.663* | 1.119 | 1.056 |
| Prkcz | 25522 | 0.684 | 0.352* | 2.042* | 1.381 |
| Ppp2r1a | 117281 | 1.191 | 1.357* | 0.969 | 1.012 |
| Pik3r6 | 497932 | 1.032 | 1.036 | 1.28 | 0.848 |
| Arg2 | 29215 | 1.214 | 0.841 | 1.127 | 1.329 |
| Stat1 | 25124 | 1.052 | 0.98 | 0.767 | 0.86 |
| Ppp1r14b | 259225 | 0.697 | 0.845 | 0.76 | 0.9 |
| Map3k6 | 313022 | 1.262 | 1.151 | 1.37 | 1.263 |
| Rhoa | 117273 | 1.022 | 1.089 | 0.974 | 1.031 |
| Rhot2 | 287156 | 1.345$ | 1.207 | 0.807 | 1.129 |
Results of IPA analysis to evaluate the effects of EX and SPRINT on expression of genes in this IPA canonical pathway. Results are expressed as fold change for the EX (OE) or SPRINT (OI) values relative to that of the sedentary OLETF value for that sample. Thus any entry that is >1.00 (italic font) reflects a gene with increased expression and any entry that is <1.00 (nonitalic font) reflects a gene with decreased expression. The * indicate a value that is significantly changed relative to sedentary OLETF rats (P < 0.01);
$
P < 0.05. The Symbol and Gene IDs are from the National Center for Biotechnology Information (NCBI) (http://www.ncbi.nlm.nih.gov/) gene bank and defined therein.