Table 3.
Intra-VP injections of dopamine and dopamine agonists produced oral dyskinesia that is comparable to that seen with intraperitoneal amphetamine.
| Treatment (intra-VP, μg/0.5μl/side) | Dyskinesia Score |
|---|---|
| Vehicle | 9±2.0 |
| Amphetamine 1mg/kg ip | 24±5.8** |
| Dopamine (10) | 49±11.4** |
| Quinpirole (13.5)# | 19±3.5** |
| SKF82958 (21.7)# | 34±9.8** |
| SCH23390 0.1mg/kg ip + SKF82958 (21.7)# | 7±3.3 |
| SCH23390 (0.1) + SKF82958 (21.7)# | 16±4.4 |
An oral dyskinesia count was assigned if the animal engaged in any one of the following: chewing, teeth-grinding, licking/tongue protrusions or yawing. The oral behaviors were quantified for one min, every five min, for a total of 13 assessment periods. Intra-VP injections are described in Table 1 legend. Intraperitoneal (ip) amphetamine served as the positive control.
#
equal molar to 10 μg dopamine. ANOVA with post doc Dunnets
* P<0.05