Table 7.
VP manipulations and effects related to drugs of abuse.
| Reference | VP Manipulation | System | Effects | Task | Result |
|---|---|---|---|---|---|
| Dallimore et al., 2006 | CNQX and AP-5 | Glutamate | Multiple | Behavioral sensitization with morphine | Blocked |
| Kalivas et al., 1991 | DAMGO | Opioid | Mu agonist | Behavioral sensitization with morphine | Expressed |
| Rokosik et al., 2013 | DAMGO | Opioid | Mu agonist | Behavioral sensitization with morphine | Expressed |
| Johnson and Napier 2000 | CTOP | Opioid | Mu | Behavioral sensitization with morphine | Blocked |
| Mickiewicz et al., 2008 | CTOP | Opioid | Mu | Behavioral sensitization with morphine | Blocked |
| Mickiewicz et al., 2009 | Morphine | Opioid | Multiple | Behavioral sensitization with morphine | Expressed |
| Zarrindast et al., 2007 | Morphine | Opioid | Multiple | Behavioral sensitization with morphine | Expressed |
| Chen et al., 2001 | MK801 | Glutamate | NMDA antagonist | Behavioral sensitization with amphetamine | Blocked |
| Skoubis and Maidment 2003 | Naloxone | Opioid | Multiple antagonist | Conditioned Place Aversion | Formed |
| Skoubis and Maidment 2003 | CTOP | Opioid | Mu antagonist | Conditioned Place Aversion | Formed |
| Gong et al., 1996 | Cocaine | DA | Multiple | Conditioned Place Preference | Formed |
| Gong et al., 1996 | Amphetamine | DA | Multiple | Conditioned Place Preference | Formed |
| Ikemoto 2003 | Cocaine | Dopamine | Multiple | Conditioned Place Preference | No effect |
| Gong et al., 1997 | Picrotoxin | GABA | Antagonist | Conditioned Place Preference | No effect |
| Gong et al., 1997 | AMPA | Glutamate | AMPA | Conditioned Place Preference | No effect |
| Gong et al., 1996 | Procaine | Sodium | Antagonist | Conditioned Place Preference | No effect |
| Gong et al., 1997 | 6-OHDA | DA/NE | NA | Conditioned place preference (cocaine) | Decrease |
| Skoubis and Maidment 2003 | Naloxone | Opioid | Multiple | Conditioned place preference (cocaine) | Attenuated |
| Dallimore et al., 2006 | CNQX and AP-5 | Glutamate | Multiple | Conditioned place preference (morphine) | Blocked |
| McAlonen et al., 1993 | Lesion | NA | NA | Conditioned place preference (sucrose) | Attenuated |
| Ikemoto 2003 | Cocaine | Dopamine | Multiple | Intracranial self-adminsitration | No effect |
| Torregrossa and Kalivas 2008 | NT8-13 | Neurotensin | Agonist | Reinstatement of cocaine-seeking maintained by conditioned reinforcer | Attenuated |
| McFarland and Kalivas 2001 | Fluphenazine | Dopamine | D1/D2 antagonist | Reinstatement of cocaine-seeking triggered by cocaine | No effect |
| McFarland and Kalivas 2001 | Baclofen/Muscimol | GABA | GABA-A/B Agonist | Reinstatement of cocaine-seeking triggered by cocaine | Decrease |
| Tang et al., 2005 | Cocaine | Multiple | Multiple | Reinstatement of cocaine-seeking triggered by cocaine | Increase |
| Tang et al., 2005 | Cocaine+Morphine | Multiple | Multiple | Reinstatement of cocaine-seeking triggered by cocaine | Mixed |
| Torregrossa and Kalivas 2008 | NT8-13 | Neurotensin | Agonist | Reinstatement of cocaine-seeking triggered by cocaine | Increase |
| Torregrossa and Kalivas 2008 | SR142948 | Neurotensin | Antagonist | Reinstatement of cocaine-seeking triggered by cocaine | No effect |
| Tang et al., 2005 | CTAP | Opioid | Mu Antag | Reinstatement of cocaine-seeking triggered by cocaine | Decrease |
| Tang et al., 2005 | Morphine | Opioid | Multiple | Reinstatement of cocaine-seeking triggered by cocaine | Increase |
| Li et al., 2009 | AMN082 | Glutamate | mGluR7 Agonist | Reinstatement of cocaine-seeking triggered by cocaine | Decrease |
| Stefanik et al. 2013 | Optogenetic inhibition of Core projection to VPdl | GABA | NA | Reinstatement of cocaine-seeking triggered by cocaine+cues | Decrease |
| McFarland et al., 2004 | Baclofen/Muscimol | GABA | GABA-A/B Agonist | Reinstatement of cocaine-seeking triggered by footshock | Decrease |
| Tang et al., 2005 | CTAP | Opioid | Mu Antagonist | Reinstatement of cocaine-seeking triggered by morphine | Blocked |
| Tang et al., 2005 | CTAP | Opioid | Mu Antagonist | Reinstatement of cocaine-seeking triggered by morphine | Blocked |
| Perry and McNally, 2013 | CTAP | Opioid | Mu Antagonist | Reinstatement of alcohol-seeking triggered by context | Blocked |
| Perry and McNally, 2013 | CTAP | Opioid | Mu Antagonist | Reinstatement of alcohol-seeking triggered by alcohol | Blocked |
| McFarland and Kalivas 2001 | Baclofen/Muscimol | GABA | GABA-A/B Agonist | Reinstatement of food-seeking triggered by food | Decrease |
| McFarland and Kalivas 2001 | Unilateral VP Baclofen/Muscimol & Contralateral mPFC baclofen/muscimol | GABA | GABA-A/B Agonist | Reinstatement of cocaine-seeking triggered by cocaine | Decrease |
| Tang et al., 2005 | CTAP | Opioid | Mu Antagonist | Reinstatement of food-seeking triggered by food | No effect |
| Rogers et al., 2008 | Baclofen/Muscimol | GABA | GABA-A/B Agonist | Reinstatement of heroin-seeking maintained by conditioned reinforcer | Blocked |
| Rodgers et al., 2008 | Baclofen/Muscimol | GABA | GABA-A/B Agonist | Reinstatement of heroin-seeking maintained by conditioned reinforcer | Blocked |
| Rogers et al., 2008 | Baclofen/Muscimol | GABA | GABA-A/B Agonist | Reinstatement of heroin-seeking triggered by heroin | Blocked |
| Rodgers et al., 2008 | Baclofen/Muscimol | GABA | GABA-A/B Agonist | Reinstatement of heroin-seeking triggered by heroin | Blocked |
| Li et al., 2009 | AMN082 | Glutamate | R7 agonist | Self-administration of cocaine | Decrease |
| Robledo and Koob 1993 | Lesion | NA | NA | Self-administration of cocaine | Decrease |
| Robledo and Koob 1993 | Lesion | NA | NA | Cocaine self-administration breaking point (progressive ratio) | No effect |
| Torregrossa and Kalivas 2008 | NT8-13 | Neurotensin | Agonist | Self-administration of cocaine | No effect |
| Torregrossa and Kalivas 2008 | SR142948 | Neurotensin | Antagonist | Self-administration of cocaine | No effect |
| Li et al., 2009 | AMN082 | Glutamate | R7 Agonist | Self-administration of cocaine breakpoint | Decrease |
| Robledo and Koob 1993 | Lesion | NA | NA | Self-administration of cocaine breakpoint | No effect |
| Torregrossa and Kalivas 2008 | NT8-13 | Neurotensin | Agonist | Self-administration of cocaine extinction | No effect |
| Torregrossa and Kalivas 2008 | SR142948 | Neurotensin | Antagonist | Self-administration of cocaine extinction | No effect |
| Harvey et al., 2002 | 3-PBC | GABA | GABA-A1 Mixed | Self-administration of cocaine ethanol | Decrease |
| June et al., 2003 | BCCt | GABA | GABA-A1 Mixed | Self-administration of ethanol | Decrease |
| Harvey et al., 2002 | 3-PBC | GABA | GABA-A1 Mixed | Self-administration of saccharine | Increase |
| Melendez et al. 2005 | Sulpiride | Dopamine | D2 antagonist | Ethanol intake | Increase |
| Kemppainen et al., 2012a | Muscimol | GABA | GABA-A Agonist | Ethanol intake | Decrease |
| Kemppainen et al., 2012a | Bicuculline | GABA | GABA-A Antagonist | Ethanol intake | Increase |
| Kemppainen et al., 2012a | Bicuculline + DAMGO | GABA + Opioid | Multiple | Ethanol intake | Blocked |
| Kemppainen et al., 2012a | Baclofen | GABA | GABA-B Agonist | Ethanol intake | Decrease |
| Kemppainen et al., 2012a | Saclofen | GABA | GABA-B Antagonist | Ethanol intake | No effect |
| Kemppainen et al., 2012b | DAMGO | Opioid | Mu agonist | Ethanol intake | Decrease |
| Kemppainen et al., 2012b | Morphine | Opioid | Agonist | Ethanol intake | Decrease |
| Kemppainen et al., 2012b | CTOP | Opioid | Mu antagonist | Ethanol intake | Increase |
Manipulation refers to an intra-VP injection or VP lesion, unless stated otherwise.