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. 2015 Dec 22;11(12):e1005711. doi: 10.1371/journal.pgen.1005711

Table 1. GO categories enriched for atherosclerosis susceptibility using expression data from aorta and liver.

Tissue Category Term Count % p-Value List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini
Aorta KEGG PATHWAY mmu05414:Dilated cardiomyopathy 19 2.35 2.28x10-07 226 89 4524 4.273 3.46 x10-05 1.73 X10-05
Aorta GOTerRM_CC_FAT GO:0015629~actin cytoskeleton 29 3.59 2.44 x10-07 500 199 10451 3.0460 9.51 x10-05 9.51 X10-05
Aorta SP_PIR_KEYWORDS actin-binding 30 3.71 4.41 x10-07 720 221 15456 2.9140 1.72 x10-04 1.72 x10-04
Aorta GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 44 5.45 3.47 x10-07 518 405 11085 2.3248 2.43 x10-04 2.43 x10-04
Aorta SP_PIR_KEYWORDS muscle protein 13 1.61 1.77 x10-06 720 49 15456 5.69 6.89 x10-04 3.45 x10-04
Aorta GOTERM_MF_FAT GO:0003779~actin binding 33 4.08 3.04 x10-06 518 283 11085 2.495 0.00213 0.001
Aorta GOTERM_CC_FAT GO:0044449~contractile fiber part 16 1.98 8.71 x10-06 500 84 10451 3.981 0.00338 0.0016
Aorta GOTERM_CC_FAT GO:0043292~contractile fiber 16 1.98 2.71 x10-05 500 92 10451 3.635 0.01047 0.0035
Aorta GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 23 2.84 5.88 x10-06 522 164 11331 3.044 0.01357 0.0045
Liver GOTERM_BP_FAT GO:0006955~immune response 47 5.85 1.44 x10-09 479 414 11331 2.68 3.05E-06 3.05E-06
Liver INTERPRO IPR006117:2-5-oligoadenylate synthetase, conserved site 6 0.74 3.38 x10-06 672 7 15054 19.201 0.00376 0.0018
Liver PIR_SUPERFAMILY PIRSF001990:class I histocompatibility antigen 7 0.87 1.14 x10-05 305 13 6642 11.72 0.00385 0.0038
Liver SP_PIR_KEYWORDS immune response 21 2.61 3.58 x10-05 669 167 15456 2.9051 0.01377 0.013
Liver SP_PIR_KEYWORDS immune response 21 2.61 3.58 x10-05 669 167 15456 2.905 0.0137 0.013
Liver INTERPRO IPR001039:MHC class I, alpha chain, alpha1 and alpha2 7 0.87 1.74 x10-04 672 20 15054 7.840 0.176 0.038
Liver INTERPRO IPR018952:2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal 6 0.74 1.06 x10-04 672 12 15054 11.200 0.1113 0.038
Liver INTERPRO IPR004020:Pyrin 7 0.87 2.34 x10-04 672 21 15054 7.467 0.230 0.042
Liver INTERPRO IPR006116:2-5-oligoadenylate synthetase, ubiquitin-like region 6 0.741 1.65 x10-04 672 13 15054 10.3392 0.168 0.045