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Rats were treated with either PBN or certain PBNDs before 2h of light adaptation followed by 2.5h of dark adaptation after which the animals were euthanized and retinas harvested for rhodopsin assay. Saline treated retina recovered ~ 75% rhodopsin in 2.5h dark. PBN and its derivatives, however, blocked rhodopsin regeneration significantly. LA, light adapted; DA, dark adapted. [* = p<0.01; ** = p<0.001; n = 4–6]
