Fig 5. Mice treated topically with PBN or PBND’s showed reduction in rhodopsin regeneration.

Dark adapted no treatment (DA-NT), no treatment light-adapted followed by dark adapted (NT LA-DA), and vehicle controls were used. Both 1% and 10% PBN were tested against 5% concentrations of PBNDs. Topical administration of assigned drug consisted of 1 drop in each eye once every 3 hours over a 6 hour period resulting in 3 total applications in light adapted mice eyes. Immediately following the 3^rd and final dose mice were placed in the dark for 1h before harvest. LA, light adapted; DA, dark adapted. [* = p<0.01; ** = p<0.001; n = 6]