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. Author manuscript; available in PMC: 2015 Dec 22.
Published in final edited form as: J Med Chem. 2015 Jun 24;58(13):5208–5217. doi: 10.1021/acs.jmedchem.5b00092

Figure 1.

Figure 1

Fragments in BioA active site. Omit Fo − Fc (3σ) electron density (mesh) is displayed about the PLP cofactor and bound ligand (above), and ligand interaction maps relating BioA and fragment molecules (below). (A) F2; (B) F3; (C) F5; (D) F7; (E) F9; (F) F10. Hydrogen bonds are shown as green dashed lines with distances (Å). Hydrophobic contacts shorter than 3.9 Å are identified by thin dashed lines. Interaction maps prepared with LigPlot+.31