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. Author manuscript; available in PMC: 2016 Sep 22.
Published in final edited form as: ACS Nano. 2015 Jul 29;9(9):9357–9372. doi: 10.1021/acsnano.5b03443

Figure 7. Reduction in IL-1β production by Ti and Al doping of fumed silica nanoparticles.

Figure 7

(A–B) IL-1β production induced by doped fumed silica in THP-1 cells. Naive THP-1 cells were treated with PMA (1 μg/mL) for 16 h. PMA-differentiated THP-1 cells were then exposed to 25–200 μg/mL of (A) Ti-doped and (B) Al-doped fumed silica nanoparticles for 24 h in the presence of LPS (10 ng/mL). IL-1β production was quantified by ELISA. *p<0.05 compared to non-doped fumed silica. (C–D) IL-1β production induced by doped fumed silica in bone marrow-derived macrophages (BMDMs). BMDMs obtained from wild type C57BL/6 mice were exposed to 25–200 μg/ml of (C) Ti-doped and (D) Al-doped fumed silica nanoparticles for 24 h in the presence of LPS (500 ng/mL). *p<0.05 compared to non-doped fumed silica.