Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2016 Sep 22.

Published in final edited form as: ACS Nano. 2015 Jul 29;9(9):9357–9372. doi: 10.1021/acsnano.5b03443

C57BL/6 (n=6) mice were exposed to 10 mg/kg of fumed silica by oropharyngeal aspiration. BAL fluid was collected to determine (A) neutrophil count, (B) IL-1β, (C) MIP-1α and (D) LIX levels at 6 h. MIN-U-SIL (MUS), a natural form of crystalline silica, was used as a positive control. ^*p<0.05 compared to control mice; ^#p<0.05 compared to fumed silica-treated mice. (E) H&E staining showed the presence of focal inflammation in the lungs, which was reduced by Ti and Al doping. The regions of focal inflammation are indicated by the arrows.

C57BL/6 (n=6) mice were exposed to 10 mg/kg of fumed silica by oropharyngeal aspiration. BAL fluid was collected to determine (A) neutrophil count, (B) IL-1β, (C) MIP-1α and (D) LIX levels at 6 h. MIN-U-SIL (MUS), a natural form of crystalline silica, was used as a positive control. ^*p<0.05 compared to control mice; ^#p<0.05 compared to fumed silica-treated mice. (E) H&E staining showed the presence of focal inflammation in the lungs, which was reduced by Ti and Al doping. The regions of focal inflammation are indicated by the arrows.