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The hypothetical Wnt-DLK1 pathway in HSC-hepatocyte crosstalk in liver regeneration is depicted. Necdin, Wnt, DLK1 positively cross-interact to cause epigenetic Pparγrepression and activate HSCs. Wnt and DLK1 produced by HSCs stimulate HSC proliferation while exerting paracrine stimulation of hepatocyte proliferation. An unidentified receptor for DLK1 is depicted as X.
