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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Hum Genet. 2015 Sep 24;134(0):1249–1262. doi: 10.1007/s00439-015-1598-6

Figure 2. Association results.

Figure 2

(a) Manhattan plot of results in GECCO/CCFR. Controls with family history and/or polyps are excluded from the analysis. Each dot represents a SNP plotted on the x-axis relative to its position in the genome, whose level of significance is represented on the y-axis. Green dots represent SNPs in LD with SNPs identified in published GWAS for CRC. Replication in CORECT was attempted for SNPs with p<10−5 (blue horizontal line). The red horizontal line indicates p=5×10−8; (b) quantile-quantile plot of p-values in (a), on the negative log scale. λ is the inflation factor (the ratio of observed to expected median); (c) quantile-quantile plot of p-values when no controls are excluded from the analysis.