Table VI.
Clinical response: sequential schedule (n = 16).
| Dose level | Dose of vorinostat | Patient | No. of prior therapies | Best response | Duration of response (weeks) | No. of cycles to best response | Total no. of cycles completed |
|---|---|---|---|---|---|---|---|
| 1 | 100 mg bid days 6–21 | 901 | 0 | NR | NA | NA | 0 |
| 902 | 1 | NR | NA | NA | 2 | ||
| 903 | 2 | CRi | 26.7 | 6 | 12 | ||
| 904 | 1 | NR | NA | NA | 3 | ||
| 2 | 200 mg bid days 6–21 | 905 | 3 | NR | NA | NA | 0 |
| 906 | 0 | NR | NA | NA | 2 | ||
| 907 | 1 | MLFS | 16.3 | 12 | 13 | ||
| 908 | 3 | NR | NA | NA | 2 | ||
| 3 | 200 mg tid days 6–21 | 909 | 0 | NR | NA | NA | 0 |
| 910 | 1 | NR | NA | NA | 3 | ||
| 911 | 1 | NR | NA | NA | 2 | ||
| 912 | 3 | NR | NA | NA | 3 | ||
| 913 | 0 | NR | NA | NA | 10 | ||
| 914 | 0 | NR | NA | NA | 1 | ||
| 915 | 4 | NR | NA | NA | 0 | ||
| 918 | 1 | NR | NA | NA | 2 |
bid, twice a day; tid, three times a day; NR, no response; CRi, complete response with incomplete blood count recovery; MLFS, morphologic leukemic free state; NA, not applicable.