Table VIII.
Decitabine pharmacokinetics parameters.
| PK parameter | Day 1 | Day 5 |
|---|---|---|
| Sequential schedule: decitabine 20 mg/m2/day (n = 3) | ||
| Mean Cmax (ng/mL) (SD) | 137.1 (126.4) | 129.9 (87.1) |
| Mean AUCt (ng·h/mL) (SD) | 102 (76.1) | 107.1 (67.3) |
| Mean AUCinf (ng·h/mL) (SD) | 105.4 (77.3) | 111 (66.2) |
| Mean t1/2 (h) (SD) | 0.36 (0.05) | 0.42 (0.18) |
| Mean CL (L/h/m2) (SD) | 254.8 (134.3) | 226.2 (121.6) |
| Concurrent schedule: decitabine 20 mg/m2/day (n = 6) | ||
| Mean Cmax (ng/mL) (SD) | 192.6 (164.1) | 235.9 (187.5) |
| Mean AUCt (ng·h/mL) (SD) | 149.1 (95.8) | 165.7 (85.8) |
| Mean AUCinf (ng·h/mL) (SD) | 152 (96.6) | 169.5 (85.2) |
| Mean t1/2 (h) (SD) | 0.36 (0.12) | 0.40 (0.17) |
| Mean CL (L/h/m2) (SD) | 202.8 (153.7) | 139.6 (55.1) |
PK, pharmacokinetics; Cmax, maximum plasma concentration; SD, standard deviation; AUCt, area under the plasma decitabine concentration versus time curve to the last sampling time; AUCinf, area under the plasma decitabine concentration versus time curve from zero to infinity; t½, terminal half-life; CL, clearance.