Table 1.

Comparison of the clinical features among the key syndromes of elevated IgE: STAT3, DOCK8, and PGM3

	STAT3	DOCK8	PGM3
Elevated serum IgE level	+++	+++	+++
Peripheral eosinophilia	+++	+++	+
Low CD4+ Th17 cells	+++	++	−
Newborn rash	+++	+	+
Eczematous dermatitis	+++	+++	+++
Recurrent skin abscesses	+++	++	++
Recurrent pneumonias	+++	++	+++
Mucocutaneous candidiasis	+++	++	−
Cutaneous viral infections	+	+++	+
Parenchymal lung changes	+++	+	++
Asthma	−	++	++
Food allergies	+	+++	++
Eosinophilic GI disease	++	++	+
Characteristic facies	+++	−	+
Retained primary teeth	+++	−	−
Scoliosis	+++	−	++
Minimal trauma fractures	+++	−	−
Hyperextensibility	+++	−	+
Vascular abnormalities	++	−	−
Autoimmunity	+	++	++
Malignancy	++	+++	++