Table 4.
Summary of in vitro release of octreotide in PBS buffer at 37°C.
| MPs polymer | Total Octreotide released (%) | Native octreotide released (%) | aAcylated octreotide released (%) | Burst release (%) | bAcylated octreotide released (%) | Release duration |
|---|---|---|---|---|---|---|
| TB | 97±6.9 | 88±6.4 | 10±0.6 | 8.4±0.8 | 13±0.4% | 105 Days |
| PBA | 87±12 | 47±7.9 | 46±5.1 | 7.1±2.3 | 53±3.0% | 330 Days |
| PBB | 53±3.2 | 9.0±0.3 | 49±3.0 | 1.4±0.3 | 92±0.5% | 330 Days |
Data represented as mean ± SD, n=4.
Burst release is total octreotide (%) released at 24h.
a
calculated with respect to %EE.
b
Calculated with respect to total octreotide released.