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. Author manuscript; available in PMC: 2016 Dec 30.
Published in final edited form as: Int J Pharm. 2015 Nov 10;496(2):676–688. doi: 10.1016/j.ijpharm.2015.11.002

Table 6.

Summary of octreotide adducts identified using UFLC-MS analysis.

Polymer Acylated species M+H/Z Retention time (min)
TB C-Octreotide 1133.5 9.9
CC-Octreotide 1246.8 12.1, 12.4
PBA L-Octreotide 1091.5 9.8
LL-Octreotide 1163.2 10.1
C-Octreotide 1133.5 9.9
CC-Octreotide 1246.8 ND
PBB G-Octreotide 1077.5 9.6
GG-Octreotide 1135.5 9.7, 10.4, 13.6
GGG-Octreotide 1193.5 12.9, 14.1
L-Octreotide 1091.5 9.8
C-Octreotide 1133.5 ND
CC-Octreotide 1246.8 ND

C- Caprolactyl, L- Lactoyl, G- Glycoyl, ND- Not detected.

Four samples for TBMPs and nine samples for PBAMPs and PBBMPs, at a month time interval, were selected for analyses.