Table 3. rs75548401 and multiple SNPs at the MAPT locus relate to age at onset.

The age at onset of Parkinson disease motor symptoms was significantly associated with rs75548401 and with multiple SNPs at the MAPT locus. A positive test statistic indicates that the minor allele related to younger age at onset; a negative test statistic indicates that the minor allele related to older age at onset.

SNP	Chr	Nearest Gene(s)	Test Statistic	Standard Error	p value
rs76763715	1	GBA (N370S)	2.646	3.284	0.420
rs75548401	1	GBA (K26R)	9.185	3.681	0.013
rs10928513	2	ACMSD/TMEM163	−4.540	18.923	0.810
rs6723108	2	ACMSD/TMEM163	−1.750	18.982	0.927
rs2390669	2	STK39	−3.667	13.287	0.783
rs11711441	3	MCCC1/LAMP3	−1.732	11.974	0.885
rs6599388	4	GAK/TMEM175	22.040	19.211	0.251
rs356219	4	SNCA	−0.537	17.916	0.976
rs11931074	4	SNCA	4.383	10.994	0.690
rs356220	4	SNCA	4.954	18.120	0.785
rs356165	4	SNCA	6.199	17.714	0.726
rs3822086	4	SNCA	3.757	10.984	0.732
rs3857059	4	SNCA	3.757	10.984	0.732
rs2736990	4	SNCA	−4.456	18.863	0.813
rs2942168	17	CRHR1/MAPT	−38.813	15.662	0.013
rs393152	17	CRHR1/MAPT	−35.708	15.692	0.023
rs7215239	17	CRHR1/MAPT	−28.984	15.795	0.067
rs1981997	17	MAPT	−38.052	15.650	0.015
rs1052553	17	MAPT	−38.849	15.655	0.013
rs17652121	17	MAPT	−38.052	15.650	0.015
rs8070723	17	MAPT	−39.225	15.659	0.012
rs199533	17	NSF/MAPT	−31.585	14.611	0.031