Table 5. No association between genetic variants and progression of UPDRS scores.
P values for association of serial measurements of UPDRS-III scores for cases in the WU group are shown for each variant. Cases with at least 3 scores measured over a minimum of 1 year were included. Only UPDRS-III scores measured in the OFF state were included in the final analysis. Inclusion of UPDRS-III scores measured in the ON state did not significantly change the results (not shown).
| SNP | Chr | Nearest Gene(s) | p value |
|---|---|---|---|
| rs76763715 | 1 | GBA (N370S) | N/A |
| rs75548401 | 1 | GBA (K26R) | 0.975 |
| rs10928513 | 2 | ACMSD/TMEM163 | 0.345 |
| rs6723108 | 2 | ACMSD/TMEM163 | 0.918 |
| rs2390669 | 2 | STK39 | 0.620 |
| rs11711441 | 3 | MCCC1/LAMP3 | 0.894 |
| rs6599388 | 4 | GAK/TMEM175 | 0.223 |
| rs356219 | 4 | SNCA | 0.714 |
| rs11931074 | 4 | SNCA | 0.801 |
| rs356220 | 4 | SNCA | 0.768 |
| rs356165 | 4 | SNCA | 0.768 |
| rs3822086 | 4 | SNCA | 0.248 |
| rs3857059 | 4 | SNCA | 0.455 |
| rs2736990 | 4 | SNCA | 0.349 |
| rs2942168 | 17 | CRHR1/MAPT | 0.741 |
| rs393152 | 17 | CRHR1/MAPT | 0.741 |
| rs7215239 | 17 | CRHR1/MAPT | 0.686 |
| rs1981997 | 17 | MAPT | 0.741 |
| rs1052553 | 17 | MAPT | 0.741 |
| rs17652121 | 17 | MAPT | 0.741 |
| rs8070723 | 17 | MAPT | 0.741 |
| rs199533 | 17 | NSF/MAPT | 0.845 |