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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Dev Biol. 2015 Oct 13;408(1):56–65. doi: 10.1016/j.ydbio.2015.10.002

Figure 8. A simplified model illustrating Pten signaling in early lung branching morphogenesis.

Figure 8

In E12.5 lung, Pten positively regulates ERK and AKT phosphorylation. The Pten-ERK pathway controls airway branching via regulation of epithelial cell migration, without measurable alterations in cell proliferation. The Pten-AKT pathway does not appear to affect epithelial cell migration.