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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Exp Neurol. 2015 Sep 26;275(0 1):46–58. doi: 10.1016/j.expneurol.2015.09.008

FIGURE 3.

FIGURE 3

Effects of the R1627H mutation on flurothyl- and 6 Hz-induced seizure susceptibility. A. Scn8aRH/+ but not Scn8aRH/RH mice have longer latencies to flurothyl-induced seizures when compared to WT littermates (one-way ANOVA, MJ and GTCS, Tukey post hoc, * P < 0.05, n = 11–12). B. Seizure severity, as measured by hindlimb extension (HE) and death, were reduced in Scn8aRH/+ and Scn8aRH/RH mice (χ2, *P < 0.05). C. Scn8aRH/+ mice are more resistant to 6 Hz seizures compared to Scn8aRH/RH and WT littermates. D. Both Scn8aRH/+ and Scn8aRH/RH mice experience less severe seizures in response to stimulus intensities of 20, 22, and 24 mA compared to WT littermates (one-way ANOVA, P < 0.0001, Dunnett’s post hoc, P < 0.001, n = 8–10).