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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Trauma Acute Care Surg. 2016 Jan;80(1):34–41. doi: 10.1097/TA.0000000000000897

Figure 6. Histone deacetylase 6 inhibition in septic shock and potential mechanisms.

Figure 6

Findings from several studies are summarized to highlight the possible mechanisms that may be involved in improving the survival. The double arrow is to acknowledge that it is unclear whether these pathways are specifically responsible for the improved survival (direct effect), or if the enhanced survival results in the observed findings (indirect effect). Attenuation of sepsis-induced bone marrow atrophy by Tubastatin A can (1) prevent bone marrow from damage; 9 (2) restore innate immune cell and macrophage populations, and increase neutrophil composition in the bone marrow (the current finding); (3) enhance circulating monocyte count and bacterial clearance 7, and alter composition of circulating blood cells. 8