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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Behav Brain Res. 2015 Nov 14;298(0 0):218–228. doi: 10.1016/j.bbr.2015.11.011

Figure 7. Effects of Reproductive State and Antenatal Immune Activation on Integrated Microglia Density in the Medial Prefrontal Cortex and CA1, CA3, and Dentate Gyrus Regions of the Hippocampus Immediately Postpartum.

Figure 7

Between Embryonic (E) day 21 and 22, rats received an injection of either lipopolysaccharide (LPS) (100μg/kg) or its saline vehicle at equal volume. Animals were euthanized on day of birth (P0) or at least 24 hours after the injection for non-pregnant animals and the density of Iba1 stain was performed in the (A) Medial Prefrontal Cortex, (B) CA1 hippocampus, (C) CA3 hippocampus, and (D) Dentate Gyrus [DG] of the hippocampus. C. Analysis of CA3 revealed a significant main effect of reproductive state (p < 0.001) such that only postpartum females had significantly higher integrated density of microglia compared to non-pregnant animals. There were no significant effects on integrated density of microglia in the mPFC, CA1, or DG regions. **: p < 0.001