Table 4. Survival analyses in PNETs, SBNETs and the combined group.
| SURVIVAL: PNETs | |||||||
|---|---|---|---|---|---|---|---|
| Hepatic replacement by tumor | n | Events | Median PFS (years) | p value | Events | Median OS (years) | p value |
| < 5% | 3 | 2 | 2.5 | .58 | 2 | 5.8 | .46 |
| ≥ 5% | 21 | 17 | 1.6 | 5 | NA | ||
| Hepatic replacement by tumor | |||||||
| < 25% | 12 | 8 | 3.2 | .09 | 3 | NA | .45 |
| ≥ 25% | 12 | 11 | 1.3 | 4 | 3.0 | ||
| # of preoperative hepatic lesions | |||||||
| < 5 | 7 | 5 | 2.8 | .18 | 2 | NA | .70 |
| ≥ 5 | 18 | 15 | 1.6 | 5 | NA | ||
| # of preoperative | |||||||
| < 10 | 12 | 10 | 3.0 | .31 | 3 | NA | .38 |
| % hepatic tumor burden debulked | |||||||
| < 70% | 8 | 7 | .51 | < .001 | 4 | 1.7 | .001 |
| ≥ 70% | 18 | 15 | 3.0 | 4 | NA | ||
| % hepatic tumor | |||||||
| < 90% | 16 | 14 | 1.3 | .05 | 6 | 6.1 | .14 |
| ≥ 90% | 10 | 8 | 4.4 | 2 | NA | ||
| CgA, PST, NKA response to debulking | |||||||
| No response | 3 | 3 | .27 | .55 | 1 | NA | .51 |
| Biochem resp. | 14 | 11 | 2.7 | 2 | NA | ||
| SURVIVAL: SBNETs | |||||||
| Hepatic replacement by tumor | n | Events | Median PFS (years) | p value | Events | Median OS (years) | p value |
| < 5% | 20 | 5 | 5.3 | .02 | 2 | NA | .28 |
| ≥ 5% | 55 | 35 | 1.9 | 15 | 9.1 | ||
| Hepatic replacement by tumor | |||||||
| < 25% | 50 | 22 | 3.2 | .02 | 9 | NA | .14 |
| ≥ 25% | 25 | 18 | 1.9 | 8 | 9.1 | ||
| # of preoperative hepatic lesions | |||||||
| < 5 | 27 | 13 | 4.2 | .02 | 6 | NA | .28 |
| ≥ 5 | 48 | 27 | 1.6 | 11 | 9.1 | ||
| # of preoperative hepatic lesions | |||||||
| < 10 | 38 | 17 | 4.2 | < .001 | 8 | NA | .20 |
| ≥ 10 | 37 | 23 | 1.6 | 9 | 9.1 | ||
| % hepatic tumor burden debulked | |||||||
| < 70% | 17 | 15 | 1.7 | .005 | 7 | 9.1 | .18 |
| ≥ 70% | 51 | 25 | 3.2 | 9 | NA | ||
| % hepatic tumor burden debulked | |||||||
| < 90% | 36 | 25 | 1.6 | .005 | 9 | 9.1 | .46 |
| ≥ 90% | 32 | 15 | 3.8 | 7 | NA | ||
| CgA, PST, NKA response to debulking | |||||||
| No response | 16 | 11 | 1.9 | .59 | 3 | 9.1 | .58 |
| Biochemical resp. | 45 | 26 | 2.6 | 10 | NA | ||
| SURVIVAL: PNET + SBNETs | |||||||
| Hepatic replacement by tumor | n | Events | Median PFS (years) | p value | Events | Median OS (years) | p value |
| < 5% | 23 | 7 52 | 5.3 | .02 | 20 | NA | .49 |
| ≥ 5% | 76 | 1.7 | 4 | 9.4 | |||
| Hepatic replacement | |||||||
| < 25% | 62 | 30 | 3.2 | .001 | 12 | NA | .06 |
| ≥ 25% | 37 | 29 | 1.3 | 12 | 9.1 | ||
| # of preoperative hepatic lesions | |||||||
| < 5 | 34 | 18 | 4.2 | .005 | 8 | NA | .25 |
| ≥ 5 | 66 | 42 | 1.6 | 16 | 9.1 | ||
| # of preoperative hepatic lesions | |||||||
| < 10 | 50 | 27 | 3.2 | < .001 | 11 | NA | .10 |
| ≥ 10 | 50 | 33 | 1.3 | 13 | 6.5 | ||
| % hepatic tumor burden debulked | |||||||
| < 70% | 25 | 22 | 1.3 | < .001 | 11 | 6.5 | .009 |
| ≥ 70% | 69 | 40 | 3.2 | 13 | NA | ||
| % hepatic tumor burden debulked | |||||||
| < 90% | 52 | 39 | 1.5 | < .001 | 15 | 6.5 | .12 |
| ≥ 90% | 42 | 23 | 3.8 | 9 | NA | ||
| CgA, PST, NKA response to debulking | |||||||
| No response | 19 | 14 | 1.9 | .44 | 4 | NA | .79 |
| Biochemical resp. | 59 | 37 | 2.6 | 12 | NA | ||
PFS: progression free survival, OS: overall survival, CgA: chromogranin A, PST: pancreastatin