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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Curr Opin Cell Biol. 2015 Nov 18;37:91–101. doi: 10.1016/j.ceb.2015.10.009

Figure 3. Significance of loss of oxi-mCs in the pathogenesis of cancers.

Figure 3

In terms of 5mC, loss of TET function results in increased 5mC and so is antagonistic to loss of DNMT function, which results in decreased 5mC. However, in terms of oxi-mC, loss of TET and DNMT function have the the same effect, a decrease of oxi-mC. Given that ablation of Tet2 or Dnmt3a in HSCs displays similar effects such as expansion, increased repopulating capacity and myeloid transformation of HSCs in murine models, loss of oxi-mCs seems more likely to be relevant to malignant transformation in hematopoietic malignancies than alterations in DNA methylation.