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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Trauma Acute Care Surg. 2016 Jan;80(1):16–25. doi: 10.1097/TA.0000000000000885

Figure 4. Circulating levels of active PAI-1 are suppressed and active tPA levels elevated in hyperfibrinolytic (HF) trauma patients compared to healthy volunteer controls.

Figure 4

(A) Active (i.e. unbound to tPA) PAI-1 is suppressed to near zero in HF compared to healthy controls. (B) Conversely, active tPA (i.e. unbound to PAI-1) levels rise nearly 20-fold in HF compared to healthy volunteers. Taken together these findings demonstrate a sharp enzymatic switching behavior between the hyperfibrinolytic and the baseline physiologic state, which hinges on the relative abundance of the active forms of the mutually inhibitor species tPA and PAI-1.