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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Trauma Acute Care Surg. 2016 Jan;80(1):16–25. doi: 10.1097/TA.0000000000000885

Figure 6. Receiver operating characteristic (ROC) curve for tPA-challenged thrombelastography (TEG) prediction of TXA-reversible hyperfibrinolysis.

Figure 6

Clot lysis in response to exogenous tPA added to the blood sample acts as a functional measure of PAI-1 reserves. The lower the levels of free PAI-1, the more exogenous tPA is left uncomplexed to cause measurable fibrinolysis, after ex vivo addition to whole blood. The area under the ROC curve was 0.94 (p <0.0005), with sensitivity and specificity optimized at 92.9% and 94.7% respectively with a threshold value of LY30 >20.8%.