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. Author manuscript; available in PMC: 2016 Dec 28.
Published in final edited form as: J Control Release. 2015 Oct 18;220(0 0):37–43. doi: 10.1016/j.jconrel.2015.10.021

Figure 1.

Figure 1

Schematic illustrating potential bias in particle tracking of heterogeneous systems. Particles that are trapped due to steric or adhesive interactions with the surrounding medium remain fixed in place, while those that avoid these interactions diffuse into and out of the focal plane. As a result, many more traces may be recorded in the focal plane for fast moving (‘Mobile’) particles vs. slow or trapped (‘Strongly hindered’) particles. Black arrows indicate moving particles for which two distinct traces were recorded due to the particles moving into and out of the focal plane multiple times.