Table 3.

Rare NeuroX pathogenic variants or of pathogenic nature unclear that are present in at least one case subject.

								Fisher’s Exact Test a
Gene	Amino acid change	dbSNP variant ID	NeuroX variant name	Minor allele count - Cases	Major allele count - Cases	Minor allele count - Controls (EVS)	Major allele count - Controls (EVS)	P	OR	LCI	UCI
PSEN2	Ser130Leu	rs63750197	exm153953	1	247	9	8591	0.248	3.86	0.09	28.04
TREM2	Arg47His	rs75932628	exm545529	1	247	22	8578	0.480	1.58	0.04	9.84

Pathogenic variants or variants of “pathogenic nature unclear” (according to the AD&FTDMDB) that were present in at least one case subject are listed along with the results from a ^aFisher’s exact test comparing allele frequencies in the 124 PCA cases versus the frequency in 4,300 European Americans, according to the Exome Variant Server (EVS). P, Fisher’s exact p-value; OR, odds ratio; LCI, lower 95% confidence interval; UCI, upper 95% confidence interval.