. Author manuscript; available in PMC: 2016 Dec 28.

Published in final edited form as: J Control Release. 2015 Oct 21;220(0 0):160–168. doi: 10.1016/j.jconrel.2015.10.037

Table 2.

Physico-Chemical Characterization of Liposomes

Formulation	Drug concentration per 10 mg/mL of liposome (μM)^a		Encapsulation (%)^a		Size (nm)^b	PDI^b	Zeta Potential (mV)
Formulation	NCL-240	Cobimetinib	NCL-240	Cobimetinib	Size (nm)^b	PDI^b	Zeta Potential (mV)
NCL-LP	361	-	98%	-	218±42	0.062	−28.4±1.7
Cobi-LP	-	53	-	86%	204±51	0.086	−29.4±2
(N+C)-LP	355	56	97%	91%	208±38	0.078	−31.6±1.2
Tf-NCL-LP	361	-	98%	-	205±59	0.145	−28.2±4.2
Tf-Cobi-LP	-	53	-	86%	201±59	0.219	−30.6±3.9
Tf-(N+C)-LP	355	56	97%	91%	212±95	0.145	−29.8±4.5

Measured by reverse-phase HPLC

Measured by dynamic light scattering. Data represent the mean particle size +/− the average particle size distribution.