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Top panel: diagram of BRI2 highlighting the changes introduced as a result of the 10 nucleotide insertion in FDD patients. The furin cleavage of the non-mutated protein in normal individuals generates Bri1-23 whereas identical processing of the mutated precursor translates into the generation of ADan, a molecule of 34 amino acids. Bottom panel: indicates the complete amino acid sequence of the BRI2-related molecules employed in the current studies
