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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Neurobiol Dis. 2015 Oct 13;85:130–143. doi: 10.1016/j.nbd.2015.10.003

Figure 5. Neurotoxicity of Bri 1-23 and ADan peptide variants.

Figure 5

SH-SY5Y cells were challenged with 50 μM peptide for up to 24 h. (A) Cell morphology was evaluated using phase contrast microscopy following 24 h peptide treatment. Magnification = X20. (B) Apoptosis was evaluated by Cell Death ELISA after 8 and 24 h peptide treatment. Results are expressed as a fold of change of nucleosome formation compared to no-peptide controls at the respective time points. (C) The release of LDH to the culture supernatant was used as a measure of plasma membrane compromise. Results are expressed as a fold of change of LDH release compared to no-peptide controls at the respective time points. For B and C, data represent the mean ± SEM of three independent experiments. * = p<.05, ***=p<.001, ****=p<.0001