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. 2015 Dec 21;4(12):e180. doi: 10.1038/oncsis.2015.37

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Copyright © 2015 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Chloroquine alleviates hydroxyurea-induced centrosome amplification. (a, b) Chloroquine inhibits hydorxyurea-induced (2 mM, 72 h) centrosome amplification in adrenocortical Y1 tumor (a) and osteosarcoma U2OS (b) cell lines. Quantitation of cells containing multiple centrosomes in the presence or absence of hydroxyurea with or without chloroquine. All results are expressed as the mean+/−s.d. from at least three independent experiments. n.s., no significance, *P<0.05, **P<0.01, ***P<0.001.