Fig 4 Updated meta-analysis of effects of LA selective interventions and mixed n-3/n-6 PUFA interventions on risk of cardiovascular death. LA selective interventions selectively increased n-6 LA without a concurrent increase in n-3 PUFAs. Mixed PUFA interventions increased n-3 PUFAs and n-6 LA. PUFA interventions replaced high SFA control diets in each trial. *Significant heterogeneity between groups. Full methods and results in part 8 of the web appendix