Table 2.
Bacteria | MBCsa |
|
---|---|---|
VipTx-I (μg/ml) | VipTx-II (μg/ml) | |
Escherichia coli | 100 | 100 |
Enterobacter aerogenes | 100 | 100 |
Proteus vulgaris | 50 | 12.5 |
Proteus mirabilis | 50 | 12.5 |
Pseudomonas aeruginosa | 100 | 100 |
Staphylococcus aureus | 50 | 6.25 |
Burkholderia pseudomallei (strain KHW) | 100 | 6.25 |
Burkholderia pseudomallei (strain TES) | 100 | 6.25 |
The MBC values were determined by a modified micro-broth dilution assay using snake venom proteins (100, 50, 25, 12.5, 6.25, 3.125 μg/ml). Antimicrobial activity of viperatoxin (VipTx-I and VipTx-II) was determined by MBCs in a solution killing assay against Gram-negative and Gram-positive bacteria.