Table 2.
Minimum bactericidal concentrations (MBCs) of viperatoxins isolated from the Indian Russell’s viper snake venom (Daboia russellii russellii).a
| Bacteria | MBCsa |
|
|---|---|---|
| VipTx-I (μg/ml) | VipTx-II (μg/ml) | |
| Escherichia coli | 100 | 100 |
| Enterobacter aerogenes | 100 | 100 |
| Proteus vulgaris | 50 | 12.5 |
| Proteus mirabilis | 50 | 12.5 |
| Pseudomonas aeruginosa | 100 | 100 |
| Staphylococcus aureus | 50 | 6.25 |
| Burkholderia pseudomallei (strain KHW) | 100 | 6.25 |
| Burkholderia pseudomallei (strain TES) | 100 | 6.25 |
a
The MBC values were determined by a modified micro-broth dilution assay using snake venom proteins (100, 50, 25, 12.5, 6.25, 3.125 μg/ml). Antimicrobial activity of viperatoxin (VipTx-I and VipTx-II) was determined by MBCs in a solution killing assay against Gram-negative and Gram-positive bacteria.