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. 2015 Dec 13;17(12):849–861. doi: 10.1016/j.neo.2015.11.005

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

MDA-MB-231-fLuc-EGFP breast cancer cell migration is associated with specific factors present in bone tissue-conditioned medium. (A) Scatter plots illustrating breast cancer cell migration as a function of leptin, IL-1β, OPG, OPN, and IL-6 levels in bone-conditioned medium generated by 13 THR specimens. Triplicate sets of bone-conditioned and control medium for each of the 13 THR specimens were used for migrations assays and MILLIPLEX analysis. Migration, detected by BLI, is plotted on the Y-axis, and analyte concentration, expressed as MFI, is plotted on the X-axis. (B) Regression analysis of MDA-MB-231-fLuc-EGFP cell migration as a function of analyte levels. Coefficients and P values generated by univariate regression analysis (before and after adjustment for age and gender) and multivariate regression analysis (age and gender included as covariates). Breast cancer cell migration was significantly associated with increasing levels of leptin and IL-1β.