Table 1.

Regulation of COX-2 in response to renal disorders and drugs

Increased COX-2 expression	Decreased COX-2 expression
Obstructive nephropathy	Neuronal NOS inhibitor: macula densa COX-2
Acute kidney injury	Lithium nephrotoxicity: medullary interstitial cell COX-2
Renal transplantation
Chronic kidney disease
Hypertension
Diabetes mellitus
Lithium nephrotoxicity
Renal artery stenosis
Glomerular diseases
Nephrotic syndrome
Heymann and lupus nephritis
Bartter's syndrome
Loop diuretics
Congestive heart failure

COX, cyclooxygenase; NOS, nitric oxide synthase.