Immunohistochemistry of β-catenin. A: In normal liver tissue, the staining was mainly positive on the cellular membrane (arrowpoint), with very weak cytoplasmic staining. × 200 B: Para-cancerous cirrhotic liver tissue showed membrane staining (arrowpoint) like normal liver tissue. C,D: For HCC, cytoplasmic and nuclear staining was dominant (arrowpoints), whereas membrane staining was rare. × 200