Table 1.
Inhibitory effect of BAM on the growth of human colorectal xenografts in nude mice*
Drug | Tumor | No. of mice | Dose (mg/kg) | Tumor weight (g) x- ± s | Tumor growth inhibition (%) |
6 | 1.300 ± 0.620 | ||||
HT-29 | 6 | 10 | 0.138 ± 0.064 | 89b | |
6 | 15 | 0.098 ± 0.074 | 92b | ||
BAM | |||||
Hce-8693 | 5 | 1.501 ± 1.445 | |||
5 | 10 | 0.154 ± 0.125 | 90b | ||
5 | 15 | 0.122 ± 0.154 | 92b |
*Treatment was started on day 3 and day 14 after HT-29 and Hce-8693 tumor transplantation, ip., twice a week, with a total of 10 injections.
P < 0.01, vs control group.