Table 1.
Concentration (μmol/L) |
Hepatoma cell growth (absorbance at 570 nm) |
||
Sense | Antisense | Oligo dT15 | |
0 | 0.83 ± 0.10 | 0.83 ± 0.10 | 0.83 ± 0.10 |
6.3 | 0.84 ± 0.08 | 0.50 ± 0.08 (39.8)a | 0.82 ± 0.11 |
12.5 | 0.76 ± 0.06 | 0.44 ± 0.04 (46.9)a | 0.87 ± 0.07 |
25.0 | 0.72 ± 0.13 | 0.42 ± 0.03 (49.4)a | 0.88 ± 0.18 |
SMMC-7721 cells were incubated with various concentrations of S-ODNs for 48 h in vitro. A specific growth inhibition was observed by the treatment with antisense S-ODNs. Values in parentheses: percent inhibition. Each value represents mean ± SD of 3 separate experiments.
P < 0.05 (Student's t test) compared with 0 μmol/L.