Table 1.

Japanese Crohn's disease patients complicated by secondary amyloidosis

Case	Age	Sex	Sites of CD	Duration of CD prior to amyloidosis diagnosis	Clinical course of CD before amyloidosis diagnosis	Major clinical manifestation of amyloidosis	type of amyloid	Proteinuria	Author (year)
1	23	M	I,C	6 year	Not well controlled	Intestinal	AA	Present	Oshima T et al[7] (1988)
2	28	M	I,C	9 year	Not well controlled	Renal	AA	Present	Tsutsui R et al[8] (1988)
3	37	M	I,C,R	11 year	Not well controlled	Renal	AA	Present	Araki T et al[9] (1989)
4	20	F	C	4 year	Not well controlled	Renal	AA	Present	Kikuchi H et al[10] (1989)
5	25	M	I	0#		Renal	AA	Present	Momiyama Y et al[11] (1989)
6	28	M	J,C	0		Renal	AA	Present	Takashima H et al[12] (1990)
7	24	M	I	0		Intestinal	AA	None	Itoh T et al[13] (1991)
8	44	M	I	8 year	Not well controlled	Intestinal	AA	None	Sakai Y et al[14] (1992)
9	26	M	I,C	13 year	Not well controlled	Renal	AA	Present	Ohwan T et al[15] (1994)
10	34	M	I,C	15 year	Unknown	Intestinal	AA	None	Yamamoto J et al[16] (1994)
11	28	M	I	12 year	Not well controlled	Renal	AA	Present	Itoh F et al[17] (1996)
12	28	M	I	7 year	Not well controlled	Renal	AA	Present	Itoh F et al[17] (1996)
13	26	M	C	4.5 year	Not well controlled	Renal	AA	Present	Yoshinaga Y et al[18] (1996)
14	43	M	C,R	15 year	Not well controlled	Renal	AA	Present	Yoshinaga Y et al[18] (1996)
15	21	M	I,C	3.5 year	Not well controlled	Renal	AA	Present	Horie Y et al[19] (1997)
16	43	M	C,R	18 year	Not well controlled	Renal	AA	Present	Muro K et al[20] (1998)
17	35	F	C	0#		Renal	AA	Present	Taki F et al[21] (1998)
18	26	M	C	11 year	Unknown	Thyroid	AA	Present	Habu S et al[22] (1999)
19	29	F	I,C,R	13 year	Not well controlled	Renal	AA	Present	Present case (1999)

^#:The diagnosis of amyloidosis preceded that of Crohn's disease. CD: Crohn's disease, J: Jejunum, I: Ileum, C:colon, R: Rectum, AA: Amyloid A