Table 1.
Baseline characteristics of women with uncomplicated urinary tract infection randomised to ibuprofen or fosfomycin. Figures are numbers of women (percentage) unless stated otherwise
| Ibuprofen (n=241) | Fosfomycin (n=243) | |
|---|---|---|
| Mean (SD) age (years) | 37.3 (14.6) | 37.3 (14.3) |
| Median (IQR) age (years) | 36.0 (24.0-50.0) | 34.0 (24.0-49.0) |
| Duration of symptoms at inclusion (days)*: | ||
| <1 | 50 (21) | 49 (21) |
| 1-2 | 104 (43) | 80 (34) |
| >2-7 | 66 (27) | 82 (34) |
| >7 | 21 (9) | 28 (12) |
| Symptoms at inclusion*: | ||
| Dysuria | 224 (93) | 218 (91) |
| Frequency/urgency | 231 (96) | 232 (97) |
| Low abdominal pain | 172 (71) | 169 (71) |
| Mean (SD) symptom severity sum score† | 6.0 (2.2) | 6.1 (2.5) |
| Median (IQR) symptom severity sum score† | 6.0 (4.0-8.0) | 6.0 (4.0-8.0) |
| Mean (SD) dysuria score‡ | 2.3 (1.0) | 2.3 (1.1) |
| Median (IQR) dysuria score‡ | 3.0 (2.0-3.0) | 2.0 (1.0-3.0) |
| Mean (SD) frequency/urgency score‡ | 2.4 (1.1) | 2.4 (1.1) |
| Median (IQR) frequency/urgency score‡ | 2.0 (2.0-3.0) | 2.0 (2.0-3.0) |
| Mean (SD) low abdominal pain score‡ | 1.3 (1.1) | 1.4 (1.1) |
| Median (IQR) low abdominal pain score‡ | 1.0 (0.0-2.0) | 1.0 (0.0-2.0) |
| Recurrent UTI§ | 42 (17) | 54 (23) |
| Mean (SD) activity impairment score¶ | 9.6 (5) | 8.9 (6) |
| Dipstick results**: | ||
| Leukocytes positive | 205 (85) | 200 (83) |
| Erythrocytes positive | 180 (75) | 189 (78) |
| Nitrite positive | 53 (22) | 46 (19) |
| Culture results: | ||
| Urine culture positive†† | 179/237 (76) | 181/234 (77) |
| E coli | 143/179 (80) | 142/181 (79) |
| Proteus mirabilis | 12/179 (7) | 8/181 (4) |
| Staphylococcus saprophyticus | 8/179 (5) | 8/181 (4) |
| Enterococcus faecalis | 3/179 (2) | 8/181 (4) |
| Streptococcus agalactiae | 0/179 (0) | 2/181 (1) |
| Klebsiella pneumoniae | 3/179 (2) | 1/181 (1) |
| Other uropathogens | 10/179 (6) | 9/181 (5) |
| Not specified | 0/179 (0) | 3/181 (2) |
| Susceptibility to fosfomycin (rate): | ||
| All uropathogens | 168/181 (93) | 162/177 (92) |
| E coli | 142/143 (99) | 142/142 (100) |
SD=standard deviation; IQR=interquartile range; UTI=urinary tract infection.
*n=239 in fosfomycin group.
†Range 0-12. Sum of daily symptom sum scores of dysuria, frequency/urgency of micturition, and low abdominal pain, each on a five point scale from 0 (not at all) to 4 (very strong/frequent).
‡Range 0-4
§UTI within past year.
¶Activity impairment assessment, sum score range 0-20.
**n=242 in fosfomycin group.
††Bacterial count >102 cfu/mL.