Table 1.
Clinical characteristics, surgical management, adjuvant chemotherapy, and follow-up of reported cases of uterine PNET.
| Author | Age | Initial sign/symptom | FIGO stage | Surgery | Chemotherapy | Follow-up |
|---|---|---|---|---|---|---|
| Bartosch et al. (2011) | 58 | Vaginal bleeding, abdominal pain, weight loss | IV | TAH, BSO, segmental enterectomy, total colectomy, right PLND | Carboplatin Paclitaxel |
Died, 11 months with sepsis from pyelonephritis |
| Celik et al. | 32 | Abdominal pain, pelvic mass | IIIA | TAH, BSO, PLND, PALND, omentectomy, appendectomy | Cisplatin Ifosfamide Adriamycin Vincristine (PIAV) |
NED, 38 months |
| Bhardwaj et al. | 50 | Vaginal bleeding, pelvic mass | IIIC | TAH, BSO, omentectomy, PLND | Unknown chemotherapy regimen | NED, 6 months |
| Odunsi et al. (2004) | 66 | Vaginal bleeding | I | TAH, BSO, omentectomy, PLND, PALND | Not done | NED, 2 years |
| Odunsi et al. (2004) | 65 | Vaginal bleeding | IIIC | TAH, BSO, omentectomy, PLND, PALND, upper vaginectomy | Cisplatin Doxorubicin Etoposide Paclitaxel |
Lung metastasis, 3 months AWD, 12 months |
| Karseladze et al. | 16 | Vaginal bleeding | I | TAH, BSO, omentectomy | Vincristine Cyclophosphamide Doxorubicin |
NED, 4 years |
| Hendrickson and Scheithauer | 12 | Vaginal bleeding, pelvic mass | IVB | TAH, LSO | Cyclophosphamide Doxorubicin Vincristine |
Pelvic recurrence, 12 months DOD, 2 years |
| Hendrickson and Scheithauer | 57 | Vaginal bleeding, uterine mass | IIB | TAH, BSO, PALND | Cisplatin Vinblastine Bleomycin |
Lung metastasis, 5 months DOD, 2 years |
| Rose et al. Ward et al. |
17 | Vaginal bleeding, pelvic mass | IIIC | RH, PLND, bilateral ovarian wedge biopsy | Vincristine Cisplatin Doxorubicin Dactinomycin Cyclophosphamide Etoposide |
NED, > 10 years |
| Daya et al. | 67 | Vaginal bleeding, enlarged uterus | IIIC | SCH, BSO | Cisplatin Doxorubicin Carboplatin 5-FU |
Persistent DOD, 6 months |
| Daya et al. | 68 | Vaginal bleeding, enlarged uterus | IVB | TAH, BSO, PLND | Cisplatin | Persistent DOD, 12 months |
| Daya et al. | 69 | Vaginal bleeding | I | TAH, BSO, PLND | Not done | NED, 6 years |
| Daya et al. | 68 | Vaginal bleeding | I | TAH, BSO | Not done | NED, 5 years |
| Molyneux et al. | 72 | Vaginal bleeding | I | TAH, BSO | Not done | DOD, 8 months |
| Fragetta et al. | 78 | Vaginal bleeding | IB | TAH, BSO, PLND | Not done | NED, 9 months |
| Sorenson et al. | 62 | Vaginal bleeding | I | TAH, BSO | Vincristine Cyclophosphamide Cisplatin |
DOD, 18 months |
| Taieb et al. | 36 | Uterine enlargement | I | RH, BSO, PLND | Not done | NR |
| Ng et al. | 48 | Vaginal bleeding | IIIC | TAH, BSO | Not done | |
| Blattner et al. (2007) | 26 | Pelvic mass noted at cesarean section | III | RH, PLND, bilateral ovarian transposition | Vincristine Doxorubicin Cyclophosphamide Etoposide |
NED, 16 months |
| Mittal et al. (2007) | 24 | Fever, abdominal pain, pelvic mass | II | TAH, BSO, omentectomy | Vincristine Doxorubicin Cyclophosphamide Ifosfamide Etoposide |
Recurrence, 1 months |
| Akbayir et al. | 22 | Vaginal bleeding, adnexal mass | I | TAH, BSO, PLND, PALND, omentectomy | Cisplatin Doxorubicin |
NED, 10 months |
| Peres et al. | 15 | Abdominal pain, fever, pelvic mass | I | TAH, PLND | Carboplatin Etoposide |
NED, 12 months |
| Varghese et al. (2006) | 43 | Vaginal bleeding, uterine enlargement | IIIC | TAH, BSO, PLND | Cytoxan Adriamycin Vincristine Etoposide |
NED, 2 months |
| Park et al. | 30 | Vaginal bleeding, uterine enlargement | IVB | None | Vincristine Doxorubicin Ifosfamide Carboplatin Etoposide |
DOD, 16 months |
| Shah et al. (2009) | 59 | Vaginal bleeding, pelvic mass | IIIC | TAH, BSO, PLND, PALND, omentectomy | Paclitaxel Carboplatin |
AWD, 12 months |
| Majeed et al. | 27 | Vaginal bleeding, uterine mass | NR | TAH/BSO | Vincristine + Etoposide + Doxorubicin + Ifosfamide/ Vincristine + Ifosfamide |
NED, 2 years |
| Ren et al. | 56 | Vaginal bleeding | IB | TAH, BSO, PLND | Ifosfamide Etoposide Cisplatin |
NED, 41 months |
| Fukunaga et al. | 54 | Unknown | NR | TAH, BSO | Cyclophosphamide Cisplatin Doxorubicin 5-FU |
AWD, 3 months |
| Venizelos et al. | 68 | Vaginal bleeding | I | TAH, BSO | Not done | NED, 10 months |
| Euscher et al. (2008) | 58 | Vaginal bleeding with palpable mass | IIIC | Unknown surgery | Not done | DOD, 2 months |
| Euscher et al. (2008) | 31 | Back pain from metastatic disease | IV | Not done | Unknown chemotherapy regimen | DOD, 20 months |
| Euscher et al. (2008) | 72 | Vaginal bleeding | IA | Unknown | Unknown | DOD, 11 months |
| Euscher et al. (2008) | 48 | Unknown | IIIC | Unknown | Unknown | Unknown |
| Euscher et al. (2008) | 81 | Vaginal bleeding | Unknown | Unknown | Unknown | Unknown |
| Euscher et al. (2008) | 66 | Pelvic mass | IIIC | Unknown surgery | Letrozole | NED, 41 months |
| Euscher et al. (2008) | 53 | Vaginal bleeding | Unknown | Unknown | Unknown | DOD, 22 months |
| Euscher et al. (2008) | 51 | Vaginal bleeding | Unknown | Unknown | Unknown | DOD, 12 months |
| Euscher et al. (2008) | 31 | Vaginal bleeding | Unknown | Unknown | Unknown | DOD, 26 months |
| Euscher et al. (2008) | 64 | Cervical polyp | IIB/ possible IIIC |
TAH, BSO | Unknown chemotherapy regimen | NED, 36 months |
| Euscher et al. (2008) | 64 | Vaginal bleeding with pain | Unknown | Unknown | Unknown | Unknown |
| Euscher et al. (2008) | 69 | Vaginal bleeding | IV by imaging | Unknown | Unknown | Unknown |
| Euscher et al. (2008) | 62 | Uterine fibroids | IIIC | Unknown | Unknown | DOD, 22 months |
| Euscher et al. (2008) | 55 | Vaginal bleeding with fibroids | IB | TAH, BSO | Unknown chemotherapy regimen | NED, 38 months |
| Euscher et al. (2008) | 52 | Unknown | IV | Unknown | Unknown | NED, 6 months |
| Euscher et al. (2008) | 58 | Vaginal pressure with passage of tissue | IV | Not done | Unknown chemotherapy regimen | NED, 6 months |
| Euscher et al. (2008) | 57 | Unknown | IIIC | Not done | Unknown chemotherapy regimen | NED, 35 months |
| Stolnicu et al. | 12 | Vaginal bleeding with passage of tissue | Unknown | Not done | Etoposide, Bleomycin, Cisplatin | NED, 36 months |
| Vignali et al. | 31 | Vaginal bleeding, intermittent abdominal pain | IIIC | Unknown | Cisplatin, Etoposide | NED, 24 months |
| Cate et al. | 25 | Vaginal bleeding, uterine inversion and prolapse | Unknown | TAH | Not done | NED, 18 months |
| Dizon et al. | 50 | Abdominopelvic pain | Unknown | TAH, BSO, omentectomy, | Carboplatin, Etoposide | NED, 16 months |
| Shimada et al. | 63 | Constipation | Unknown | TAH, BSO | Cyclophosphamide, Vincristine, Adriamycin | NED, 24 months |
| Yi et al. | 29 | Abdominal swelling and pain | IVB | TAH, BSO, PALND, PLND, omentectomy | Neoadjuvant docetaxel and carboplatin. Vincristine, Adriamycin, Cyclophosphamide |
AWD, 18 months Liver metastasis |
| Aminimoghaddam et al. | 32 | Vaginal bleeding, abdominal pain | TAH, BSO, PLND | Holoxan, Mesna, Cisplatin, Paclitaxol, Carboplatin | AWD, unknown | |
| Current case | 26 | Vaginal bleeding, uterine mass | IV | TAH, BSO, omentectomy, PLND | Carboplatin Etoposide Avastin |
NED, 48 months |
TAH, total abdominal hysterectomy; LSO, left salpingo-oophorectomy; DOD, died of disease; BSO, bilateral salpingo-oophorectomy; PALND; pelvic and para-aortic lymph node dissection; RH, radical hysterectomy; PLND, pelvic lymph node dissection; NED, no evidence of disease; SCH, supracervical hysterectomy; AWD, alive with disease; NR, not recorded.