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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Curr Opin Hematol. 2015 Jul;22(4):302–308. doi: 10.1097/MOH.0000000000000150

FIGURE 1.

FIGURE 1

The role of mTOR in HSC maintenance and transduction. Gray arrows denote upstream regulators of mTOR that are important for HSC maintenance (green: mTOR activators; red: mTOR inhibitors). Black arrows denote downstream effectors regulated by mTOR. mTOR is the active kinase subunit of two complexes: mTORC1 and mTORC2. mTORC1 regulates three processes implicated in HSC maintenance, shown in orange [26,29,30,31▪]. In addition to promoting HSC maintenance, mTOR inhibition also enhances lentiviral vector transduction of HSCs by enhancing one or more early steps of vector endocytosis, shown in blue, potentially via an mTORC2-mediated mechanism [8▪▪]. HSC, hematopoietic stem cell; mTOR, mammalian target of rapamycin.