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. Author manuscript; available in PMC: 2015 Dec 23.
Published in final edited form as: Chem Rev. 2015 Jul 8;115(19):11109–11146. doi: 10.1021/acs.chemrev.5b00109

Figure 19.

Figure 19

Immunization with two TLR agonists induces persistent germinal centers and long-lived antibody-forming cells in draining lymph nodes. C57BL/6 mice were immunized with OVA encapsulated in nanoparticles with TLR-4 agonist (MPL) and TLR-7 agonist (R837) plus antigen. (A) Antibody titers 4 weeks post-prime. (B) Germinal centers (GCs) were counted in draining lymph node (LN) sections over time. (C) ELISPOT assay quantification of antibody-secreting cells in lymph nodes over time. Adapted from Kasturi et al.309 Reprinted with permission from reference 309. Copyright 2011 Macmillan Publishers Ltd.

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