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. Author manuscript; available in PMC: 2015 Dec 23.
Published in final edited form as: Chem Rev. 2015 Jul 8;115(19):11109–11146. doi: 10.1021/acs.chemrev.5b00109

Figure 6.

Figure 6

Antigens bound to the surface of liposomes generate a significantly higher antibody tire. Mice were immunized with liposomes containing 2 µg MPLA associated with peptide. (a) no peptide (b) 60 µg peptide internally encapsulated in 5 µmol lipid (c) 65 µg peptide internally encapsulated in 1 µmol lipid (d) 60 µg peptide covalently bound to liposome surface (I µmol lipid) (e) 60 µg peptide co-injected with liposomes (1 µmol lipid) to which no peptide is bound (f) peptide conjugated to ovalbumin in Freund’s complete adjuvant with boosters in Freund’s incomplete adjuvant. IgG titer was measured after the third injection with an interval of three weeks between each injection.115 Reprinted with permission from reference 115 Copyright 1993 Pergamon Press Ltd.