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. 2015 Dec 22;3:14. doi: 10.1186/s40170-015-0140-6

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© Markert and Vazquez. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The hallmarks of cancer. The core hallmarks of cancer are arranged around the circle. Given their function, the molecular hallmarks are divided into those promoting cell proliferation (white background) and those promoting tissue remodelling (grey background). Genome instability has a special location in between because it is the molecular mechanism driving the emergence of the other hallmarks and the same time the potential transition between the physiological states of proliferation and remodelling. Deregulated metabolism has also a special location in between because it is a necessary requirement for both cell proliferation and tissue remodelling, and at the same time, metabolic alterations may be the cause or drive transitions between proliferation and remodelling