Figure 4.
Multispectral analysis: (A) ADC, T2 values and proton density (PD) maps shown for a colorectal cancer murine xenograft. (B) K-means clustering is performed and decision boundaries are formed. (C) Four tissue categories are produced (viable tumor, subcutaneous (SC) fat and two necrotic regions (differentiated from each other by the T2 signal) that relate to pathology as seen on the H&E section. (D) The anti-vascular effect of G6-31 in treated animals is significant viable tumor tissue but not significant in necrotic regions. Adapted from Carano et al. (76) and Berry et al. (79).