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The scheme of RXRα/tRXRα and its ligands (A) Schematic representation of RXRα and tRXRα. DBD, DNA-binding domain; LBD, ligand-binding domain; AF-1, activation function 1; AF-2, activation function 2. (B) Chemical structures of 9-cis-RA, Targretin, UAB30 and peretinoin.
